An improved synthesis of 1,6-anhydro-2,3
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Stéphane Caron; Andrew I. McDonald; Clayton H. Heathcock
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Article
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1996
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Elsevier Science
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English
⚖ 176 KB
In our effort towards the preparation of squalene synthase inhibitor zaragozic acid A (squalestatin S l, 1) [1-3], we have employed ketone 2, a 1,6-anhydropyranose [4]. As our need for larger quantities of ketone 2 increased, we realized that we needed an improved synthesis of this compound. Althoug