15N NMR study of isoquinoline alkaloids

✍ Scribed by Radek Marek; Otakar Humpa; Jiří Dostál; Jiří Slavík; Vladimír Sklenář

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 167 KB
• Volume: 37
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/(sici)1097-458x(199903)37:3<195::aid-mrc435>3.0.co;2-d

✦ Synopsis

15N NMR chemical shifts of 40 tertiary and quaternary isoquinoline alkaloids of six constitutional types are reported. The selected compounds belong to the classes of benzo[c]phenanthridine, protoberberine, benzylisoquinoline, aporphine, pavinane, and b-carboline-proaporphine alkaloids. The 15N chemical shifts were measured by gradient-enhanced inverse-detected single-quantum (GSQMBC) and multiple-quantum (GHMBC) multiple-bond correlation experiments. The 1HÈ15N long-range coupling constants determined from the phasesensitive GSQMBC spectra are also reported in order to facilitate optimization of multiple-bond correlation experiments.