1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) an efficient homogeneous catalyst for aldol condensation reactions. Study of the catalyst recovery and reusability using CO2

✍ Scribed by Iuliana Cota; Francisco Medina; Jesús E. Sueiras; Didier Tichit

• Publisher: Elsevier Science
• Year: 2011
• Tongue: French
• Weight: 716 KB
• Volume: 52
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.11.032

✦ Synopsis

In this work it was shown that TBD (1,5,7-triazabicyclo[4.4.0]dec-5-ene), a cheap and commercially available guanidine base, efficiently catalyzes aldol condensation reactions yielding interesting products for pharmacological and fragrance industries. This methodology works under solvent-less conditions and affords with very good conversions the corresponding products. Moreover, a simple and effective separation protocol using the CO 2 fixation was employed. The catalyst could be recovered and re-used for three consecutive runs without significant loss of activity.