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152 Simvastatin improves sinusoidal endothelial dysfunction in CCI4 cirrhotic rats


Book ID
117373664
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
242 KB
Volume
42
Category
Article
ISSN
0168-8278

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In cirrhosis, intrahepatic endothelial dysfunction is one of the mechanisms involved in the increased resistance to portal blood flow and therefore in the development of portal hypertension. Endothelial nitric oxide synthase (eNOS) uncoupling due to deficiency of tetrahydrobiopterin (BH4) results in