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152 MDM2 SNP 309 polymorphism is associated with increased risk of initiation and early age of onset in nasopharyngeal carcinoma development

โœ Scribed by H. Sousa; M. Pando; R. Catarino; E. Breda; R. Medeiros


Book ID
119601941
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
47 KB
Volume
8
Category
Article
ISSN
1359-6349

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Role of the MDM2 SNP309 polymorphism in
โœ Hugo Sousa; Mafalda Pando; Eduardo Breda; Raquel Catarino; Rui Medeiros ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 171 KB

Recent studies refer that amplification/overexpression of the principal negative regulator of p53 (Mdm2) is frequently found in several malignancies. Several studies have associated a polymorphism (SNP309 T/G) in the promoter region of MDM2 with higher levels of this protein, which will favor p53-pa