Role of the MDM2 SNP309 polymorphism in
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Hugo Sousa; Mafalda Pando; Eduardo Breda; Raquel Catarino; Rui Medeiros
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Article
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2010
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John Wiley and Sons
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English
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Recent studies refer that amplification/overexpression of the principal negative regulator of p53 (Mdm2) is frequently found in several malignancies. Several studies have associated a polymorphism (SNP309 T/G) in the promoter region of MDM2 with higher levels of this protein, which will favor p53-pa