Piritrexim (PTX) is a newly developed lipid-soluble folate antagonist that crosses the cell membrane by a simple, rapid, carrier-independent diffusion process. A Phase II study was conducted to evaluate the activity of PTX in 34 patients with previously chemotherapy-naive squamous cell cancer of the
✦ LIBER ✦
152. Concomitant chemo-radiotherapy in patients with advanced, pimary unrespectable head and neck cancers preliminary results of phase II study
✍ Scribed by W. Sąsiadek; T. Rutkowski; A. Wygoda; M. Syguła; B. Pilecki; A. Mucha-Małecka; M. Goleń; W. Przeorek; K. Składowski
- Publisher
- Wielkopolskie Centrum Onkologii
- Year
- 2003
- Tongue
- Polish
- Weight
- 208 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1507-1367
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## Abstract ## BACKGROUND: A randomized phase 2 study was performed to investigate the efficacy/toxicity of combining concomitant boost radiation and weekly carboplatin/paclitaxel with or without amifostine in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN). ##