1.505 Pathophysiology of levodopa-induced dyskinesia in Parkinson's disease: Role of pre- and postsynaptic mechanisms
β Scribed by G. Linazasoro
- Book ID
- 117752806
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 51 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1353-8020
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## Abstract Recent studies in animal models of Parkinson's disease (PD) have provided evidence that dopamine released from spared serotonin afferents can act as a trigger of dyskinetic movements induced by repetitive, low doses of levodopa. Serotonin neurons have the capacity to store and release d
Parkinson's disease (PD) patients vary widely in their response to levodopa treatment, and this variation may be partially genetic in origin. We determined whether particular dopamine and opioid receptor polymorphisms were associated with risk of earlier onset of dyskinesia side effects during levod