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1,5-Benzodiazepines as CCK-B antagonists. Effect of halogen substitution at the benzo-fused ring on potency and selectivity

✍ Scribed by Giovanni Curotto; Daniele Donati; Giorgio Pentassuglia; Antonella Ursini


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
251 KB
Volume
5
Category
Article
ISSN
0960-894X

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Synthesis and evaluation of novel 1,5-Be
✍ Gabriella Finizia; Daniele Donati; Beatrice Oliosi; Maria Elvira Tranquillini; A πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 247 KB

Abstt~tct: The synthesis and biological evaluation of both 3-ureido and 3-carbamate derivatives of 1,5benzodiazepines bearing bulky alkyl substituents at N-1 and N-5 positions is reported. Their activity as CCK-B receptor antagonists is discussed and compared with the related N-5-phenyl derivatives.