𝔖 Bobbio Scriptorium
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1471 POSTER Therapeutic benefit of combining AQ4N with radiation

Book ID
122606301
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
139 KB
Volume
3
Category
Article
ISSN
1359-6349

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A cytochrome P450 2B6 meditated gene therapy strategy to enhance the effects of radiation or cyclophosphamide when combined with the bioreductive drug AQ4N
✍ Verna McErlane; Anita Yakkundi; Helen O. McCarthy; Ciara M. Hughes; Laurence H. πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 181 KB

## Abstract ## Background AQ4N is metabolised in hypoxic cells by cytochrome P450s (CYPs) to the cytotoxin AQ4. Most solid tumours are known to contain regions of hypoxia whereas levels of CYPs have been found to vary considerably. Enhancement of CYP levels may be obtained using gene‐directed enzy