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146 A Central Role for Interleukin 27 and IL-6 Mediated Activation of STAT3 in T Cell Production of IL-10

✍ Scribed by Jason S. Stumhofer; Jonathan Silver; Arian Laurence; Paige M. Porrett; Laurence A. Turka; Matthias Ernst; Christiaan J.M. Saris; John J. O′Shea; Christopher A. Hunter

Book ID
116398038
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
66 KB
Volume
39
Category
Article
ISSN
1043-4666

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## Abstract Human T‐cell leukemia virus type‐I (HTLV‐I) encodes for the viral protein Tax, which is known to significantly disrupt transcriptional control of cytokines, cytokine receptors and other immuno‐modulatory proteins in T cells. Specific dysregulation of these factors can alter the course a