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145 Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in the treatment of lethal vaccinia virus infection in mice with severe combined immune deficiency (SCID): J. Neyts and E. De Clercq Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium


Book ID
118393214
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
66 KB
Volume
20
Category
Article
ISSN
0166-3542

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Efficacy of (S)-1-(3-hydroxy-2-phosphony
✍ Johan Neyts; Erik De Clercq πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 527 KB

## Abstract Severe combined immune deficient (SCID) mice inoculated intravenously with vaccinia virus (VV) became sick within 6–8 days and died 10–12 days after infection. Tail lesions developed and the number depended on the virus inoculum. Age‐matched immunocompetent NMRI mice similarly infected