Genotypic and phenotypic analysis of var
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Robert A. Fridell; Chunfu Wang; Jin-Hua Sun; Donald R. O'Boyle II; Peter Nower;
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Article
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2011
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John Wiley and Sons
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English
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The NS5A replication complex inhibitor, BMS-790052, inhibits hepatitis C virus (HCV) replication with picomolar potency in preclinical assays. This potency translated in vivo to a substantial antiviral effect in a single-ascending dose study and a 14-day multiple-ascending dose (MAD) monotherapy stu