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14-P023 Mouse pluripotent stem cell models of a human cardiac sodium channelopathy

✍ Scribed by Richard Davis; Christian Freund; Leon Tertoolen; Carol Ann Remme; Connie Bezzina; Christine Mummery


Book ID
119328172
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
40 KB
Volume
126
Category
Article
ISSN
0925-4773

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## Background Down syndrome (DS), caused by trisomy of human chromosome 21 (HSA21), is the most common genetic cause of mental retardation in humans. Among complex phenotypes, it displays a number of neural pathologies including smaller brain size, reduced numbers of neurons, reduced dendritic spin