𝔖 Bobbio Scriptorium
✦   LIBER   ✦

1,4-Benzodiazepines

✍ Scribed by Scott J. Childress; M. I. Gluckman

Book ID
102913079
Publisher
John Wiley and Sons
Year
1964
Tongue
English
Weight
851 KB
Volume
53
Category
Article
ISSN
0022-3549

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✦ Synopsis

HE DISCOVERY of chlordiazepoxide,' 'i-chloro-T2-rnethylamino-5-phenyl-3H-1,4-benzodiazepine 4-oxide (I) (l), which prescription surveys indicate is the most frequently prescribed new drug in the United States, has brought about a considerable amount of work on the chemistry and biological activity of 1,4-benzodiazepines. A second benzodiazepine, 7-chloro-l-methyl-5phenyl-l,3-dihydro-BH-I , 4-benzodiazepin-2-one (11) (2, 3), has been marketed as diazepam2 Two other benzodiazepines have been given extensive clinical study: 7-nitro-5-phenyl-l,3-Rmived from the Research Division, Wyeth Laboratories. Inc..

📜 SIMILAR VOLUMES

Quinazolines et benzodiazépines-1,4. LX
Quinazolines et benzodiazépines-1,4. LX Imidazo[5,1-c]benzodiazépines-1,4
✍ Roland Jaunin; Wolf Arnold 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 German ⚖ 978 KB

## Abstract Upon treatment with oxalyl chloride followed by reaction with the appropriate nucleophile, the 3‐carbamoyl‐benzodiazepines **6**, **7** and **8** were converted stereospecifically to the tricyclic compounds **12, 13, 14, 16** and **19**. Epimerization of **19** in presence of __p__‐tolu