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13C NMR evidence of the slow exchange of tryptophans in dihydrofolate reductase between stable conformations

✍ Scribed by Robert E. London; John P. Groff; Raymond L. Blakley


Book ID
118313922
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
434 KB
Volume
86
Category
Article
ISSN
0006-291X

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~3C-based three-dimensional 1H-1H correlation experiments have been used to determine essentially complete 13C and 1H resonance assignments for the amino acid side chains of uniformly 13C/15N labelled L. casei dihydrofolate reductase in a complex with the drug methotrexate. Excellent agreement is ob