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13C-Methyl isocyanide as an NMR probe for cytochrome P450 active sites

✍ Scribed by Christopher R. McCullough; Phani Kumar Pullela; Sang-Choul Im; Lucy Waskell; Daniel S. Sem


Book ID
106401602
Publisher
Springer Netherlands
Year
2009
Tongue
English
Weight
388 KB
Volume
43
Category
Article
ISSN
0925-2738

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We designed and synthesized a new class of 13 C-labeled NMR probe, 13 C-IQ-Gd, to monitor one-electron reductions by cytochrome:P450 (CYP450) reductase under hypoxic conditions. 13 C-IQ-Gd consisted of a Gd 3+ -diethylene triamine pentaacetic acid (DTPA) complex unit and an indolequinone ( 13 C-IQ)