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13C isotope effects on 1H chemical shifts: NMR spectral analysis of 13C-labelled D-glucose and some 13C-labelled amino acids

✍ Scribed by Mika Tiainen; Hannu Maaheimo; Pasi Soininen; Reino Laatikainen

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
187 KB
Volume
48
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The one‐ and two‐bond ^13^C isotope shifts, typically −1.5 to −2.5 ppb and −0.7 ppb respectively, in non‐cyclic aliphatic systems and up to −4.4 ppb and −1.0 ppb in glucose cause effects that need to be taken into account in the adaptive NMR spectral library‐based quantification of the isotopomer mixtures. In this work, NMR spectral analyses of some ^13^C‐labelled amino acids, D‐glucose and other small compounds were performed in order to obtain rules for prediction of the ^13^C isotope effects on ^1^H chemical shifts. It is proposed that using the additivity rules, the isotope effects can be predicted with a sufficient accuracy for amino acid isotopomer applications. For glucose the effects were found strongly non‐additive. The complete spectral analysis of fully ^13^C‐labelled D‐glucose made it also possible to assign the exocyclic proton signals of the glucose. Copyright © 2009 John Wiley & Sons, Ltd.

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