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13C and15N—Chemical Shift Anisotropy of Ampicillin and Penicillin-V Studied by 2D-PASS and CP/MAS NMR

✍ Scribed by Oleg N. Antzutkin; Young K. Lee; Malcolm H. Levitt

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
250 KB
Volume
135
Category
Article
ISSN
1090-7807

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✦ Synopsis

The principal values of the chemical shift tensors of all 13 C and 15 N sites in two antibiotics, ampicillin and penicillin-V, were determined by 2-dimensional phase adjusted spinning sideband (2D-PASS) and conventional CP/MAS experiments. The 13 C and 15 N chemical shift anisotropies (CSA), and their confidence limits, were evaluated using a Mathematica program. The CSA values suggest a revised assignment of the 2-methyl 13 C sites in the case of ampicillin. We speculate on a relationship between the chemical shift principal values of many of the 13 C and 15 N sites and the ␤-lactam ring conformation.

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