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13C and 1H NMR Study of the Metabolic Degradation of 4-Pentenoate in Different Dog Nephron Segments

✍ Scribed by Yvan Boulanger; Hong Wong; Angelica Fleser; Fernando Commodari; Patrick Vinay

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
384 KB
Volume
28
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The metabolism of 4‐pentenoate in isolated kidney tubules has been investigated by ^1^H and ^13^C NMR. The 4‐pentenoate metabolite, 3‐keto‐4‐pentenoyl‐CoA, accumulated in proximal tubules only and its formation could be competitively inhibited by octanoate. 4‐Pentenoate was metabolized in thick ascending limbs but not in papillary collecting ducts.© 1992 Academic Press,Inc.

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