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139. Assessing prepulse inhibition and P50 suppression in a single test session

✍ Scribed by G.A. Light; D.L. Braff


Book ID
119407806
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
18 KB
Volume
47
Category
Article
ISSN
0006-3223

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A fast and robust LC/MS-based cytochrome P450 (CYP) inhibition assay, using human liver microsomes, has been fully developed and validated for the major human liver CYPs. Probe substrates were phenacetin, diclofenac, S-mephenytoin, and dextromethorphan for CYP1A2, CYP2C9, CYP2C19, and CYP2D6, respec