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138 Double strand break repair in human mitochondrial extracts

✍ Scribed by Senyene E. Hunter; Bennett Van Houten; Joel Meyer

Book ID
116752043
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
41 KB
Volume
10
Category
Article
ISSN
1567-7249

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## Abstract Cells, which lacked the activity of the nuclease Artemis, retained approximately 10% of unrepaired double strand breaks (DSBs) at later timepoints after ionizing radiation. Ionizing radiation induced hyperphosphorylation of Artemis mainly by ATM and in ATM deficient cells to a minor ext