We sought evidence for the involvement of mutations in the amyloid precursor protein gene (APP) in the pathogenesis of schizophrenia in two ways. First, linkage analysis was performed in a sample of 24 families multiply aβ¬fected with schizophrenia. The genotypes were studied for GT12 (D21S210), a hi
138 - Association between schizophrenia and markers on chromosome 6p21
β Scribed by V.L. Nimgaonkar; W.A. Rudert; F. Zhang; K. Gentry; Y. Barron; A. Snider; X.R. Zhang; R. Ganguli; M. Trucco
- Book ID
- 119559062
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 113 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0920-9964
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Previous studies have indicated possible linkage of schizophrenia with chromosome 6p21-24. In an attempt to replicate these findings, we studied the linkage of schizophrenia with nine markers on chromosome 6p21-24 in 39 Taiwanese schizophrenic nuclear families with at least two affected siblings. Tw
Linkage disequilibrium (LD) is a potentially powerful tool for the localization of disease genes for complex disorders. Most prior studies of the relationship between genetic distance and LD have examined only very short distances, focusing on the role of LD in fine-mapping and positional cloning. W