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137 Docasahexaenoic Acid Induces Apoptosis Through Reactive Oxygen Species-dependent ERK and JNK Activation in Human Ovarian Cancer Cells

✍ Scribed by K. Lim; S. Jeong; N. Kim; K. Jing; S. Shin; H. Oh; J.Y. Heo; J.I. Park; W.H. Yoon; B.D. Hwang


Book ID
117662674
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
55 KB
Volume
48
Category
Article
ISSN
0959-8049

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## Abstract Fenretinide, which mediates apoptosis in neuroblastoma cells, is being considered as a novel therapeutic for neuroblastoma. The cytotoxic mechanisms of fenretinide, however, have not been fully elucidated. Sustained‐activation of JNK and p38 MAPK signaling has been shown recently to hav