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1346 UP-Regulation of protein kinase c isozymes upon induction of apoptosis in cerebellar granule neurons

✍ Scribed by Tomio Ono; Yoshiko Akita; Klas Blomgren; Seiichi Kawashima


Book ID
119130459
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
111 KB
Volume
25
Category
Article
ISSN
0168-0102

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Cerebellar granule neurons isolated from 7-day-old rats and cultured in normal medium undergo apoptosis, but remain healthy under depolarizing conditions with elevated K Ψ‰ (ΠΌ25 mM) or in the presence of brain-derived neurotrophic factor. Northern blot analysis showed that cyclin D1 mRNA was upregula