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1,3,4-Thiadiazoles. XI. Synthesis and behaviour of 4-Alkyl-5-acyl-1,3,4-thiadiazolines

✍ Scribed by Andreina Alemagna; Tullio Bacchetti


Book ID
112125505
Publisher
Journal of Heterocyclic Chemistry
Year
1978
Tongue
English
Weight
131 KB
Volume
15
Category
Article
ISSN
0022-152X

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Acylation of 5-amino-3H-1,3,4-thiadiazol
✍ Do Young Ra; Nam Sook Cho; Jae Joo Cho 📂 Article 📅 1998 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 364 KB

## Abstract Acylation of 5‐amino‐3__H__‐1,3,4‐thiadiazolin‐2‐one (2) was undertaken selectively at either the 3‐NH position or at 5‐amino group depending on reaction conditions. The 3‐NH is highly acidic and acylation takes place with acid anhydrides at this position in high yields in the presence