1332 Protective effects of adenosine against hypoxic injury in cultured rat cortical neurons
β Scribed by Yutaka Tamura; Hirohito Shiomi
- Book ID
- 119130446
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 90 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0168-0102
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Mounting evidence has suggested that paeonol possesses plenty of pharmacologic actions. Our research is to determine if paeonol can protect cultured rat hippocampal neurons from oxygen-glucose deprivation(OGD)-induced injury and elucidate the underlying mechanism. We cultivated the rat hippocampal n
## Abstract Mitochondrial respiration is inhibited in cells exposed to hypoxia, and the oxidation of NADH to NAD^+^ is blocked. As a result, oxidation reactions requiring NAD^+^ are blocked, disrupting cellular metabolism. We studied the influence of methylene blue, which oxidizes NADH, on hypoxic