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1330 EFFECTS OF URSODEOXYCHOLIC ACID AND PIOGLITAZONE ON HEPATOCYTES CHANGES IN NASH PATIENTS

✍ Scribed by Virstyuk, N.G.; Deltsova, O.I.; Geraschenko, S.B.; Kovalchuk, L.E.


Book ID
121971064
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
62 KB
Volume
56
Category
Article
ISSN
0168-8278

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Hepatic bile acid concentrations are elevated in chronic cholestasis because of reduced canalicular excretion and active ileal absorption of the fraction eliminated in the gut. Ursodeoxycholic acid (UDCA) reduces the intestinal absorption of endogenous bile acids, thereby diminishing the concentrati