1320 BDNF (brain-derived neurotrophic factor) induces glutamate and aspartate release from cultured rat CNS neurons
β Scribed by Tadahiro Numakawa; Naoto Sakai; Nobuyuki Takei; Hiroshi Hatanaka
- Book ID
- 119523376
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 112 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0168-0102
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## Abstract We reported previously that BDNF induced glutamate release was dependent on intracellular Ca^2+^ but not extracellular Ca^2+^ in cerebellar neurons (Numakawa et al., 1999). It was revealed that the release was through a nonβexocytotic pathway (Takei et al., 1998; Numakawa et al., 1999).
## Abstract The effects of transforming growth factor (TGF)βΞ²1 on expression of brainβderived neurotrophic factor (BDNF) and its highβaffinity receptor, TrkB, in neurons cultured from the cerebral cortex of 18βdayβold embryonic rats were examined. BDNF mRNA was significantly increased from 24β48 hr