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1320 BDNF (brain-derived neurotrophic factor) induces glutamate and aspartate release from cultured rat CNS neurons

✍ Scribed by Tadahiro Numakawa; Naoto Sakai; Nobuyuki Takei; Hiroshi Hatanaka


Book ID
119523376
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
112 KB
Volume
28
Category
Article
ISSN
0168-0102

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## Abstract We reported previously that BDNF induced glutamate release was dependent on intracellular Ca^2+^ but not extracellular Ca^2+^ in cerebellar neurons (Numakawa et al., 1999). It was revealed that the release was through a non‐exocytotic pathway (Takei et al., 1998; Numakawa et al., 1999).

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## Abstract The effects of transforming growth factor (TGF)‐β1 on expression of brain‐derived neurotrophic factor (BDNF) and its high‐affinity receptor, TrkB, in neurons cultured from the cerebral cortex of 18‐day‐old embryonic rats were examined. BDNF mRNA was significantly increased from 24–48 hr