132 In vitro and in vivo activity of N,N′-bisheteryl derivatives of dispirotripiperazine : M. Schmidtke1, R. Egerer1, A. Stelzner1, V. Makarov2 1Institute for Virology, Friedrich Schiller University, Winzerlaer Str. 10, 07745 Jena, Germany, 2State Scientific Center of the Russian Federation NIOPIK, B. Sadovaya str. 1, block 4, 103787 Moscow, Russia