131 I]Metaiodobenzylguanidine ([ 131 I]MIBG) targeted radiotherapy is effective in debulking childhood neuroblastoma. The high-energy beta-emitter [ 131 I]MIBG is, however, not very well suited to treat submillimeter tumors. The [ 125 I]MIBG emission is more fully absorbed in small target volumes an
โฆ LIBER โฆ
131I MIBG therapy in neuroblastoma: Mechanisms, rationale, and current status
โ Scribed by Tepmongkol, Supatporn; Heyman, Sydney
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 70 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0098-1532
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โฆ Synopsis
I MIBG has been used as palliative treatment of neuroblastoma patients with recurrent or persistent disease who failed other modalities of treatment. Since the results were promising, the concept arose of using it in conjunction with other modalities, either as an up-front treatment or as combination therapy. This ar-ticle reviews the principle of 131 I MIBG treatment, in conjunction with other modalities currently used for the treatment of neuroblastoma, in an attempt to improve the final outcome.
๐ SIMILAR VOLUMES
[131I]- and [125I]metaiodobenzylguanidin
โ
Marja Rutgers; Corine K.M. Buitenhuis; Martin A. van der Valk; Cees A. Hoefnagel
๐
Article
๐
2000
๐
John Wiley and Sons
๐
French
โ 389 KB