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(1→3)-α-d-glucan from an alkaline extract of Agrocybe cylindracea, and antitumor activity of its O-(carboxymethyl)ated derivatives

✍ Scribed by Tadashi Kiho; Isao Yoshida; Katsuyuki Nagai; Shigeo Ukai; Chihiro Hara

Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 447 KB
Volume: 189
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(89)84103-5

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✦ Synopsis

The structure of an alkali-soluble D-glucan (AG-AL) from the fruit body of Agrocybe cylindracea was investigated by a combination of chemical and spectroscopic methods indicating that it was a linear (1----3)-alpha-D-glucan (molecular weight, approximately 560,000), [alpha]20D +195 degrees (c 0.5, M sodium hydroxide). Both water-soluble and gelatinous products obtained by O-(carboxymethyl)ation of AG-AL showed potent antitumor activity against the solid form of Sarcoma 180 in mice, although the native D-glucan had little effect on the tumor.

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