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[1,3]-Transfer of Chirality During the Nicholas Reaction in γ-Benzyloxy Propargylic Alcohols.

✍ Scribed by David D. Diaz; Miguel A. Ramirez; Victor S. Martin


Publisher
John Wiley and Sons
Year
2006
Weight
43 KB
Volume
37
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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[1,3]-Transfer of Chirality during the N
✍ David D. Díaz; Miguel A. Ramírez; Víctor S. Martín 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 331 KB 👁 1 views

## Abstract A highly regio‐ and stereoselective intramolecular [1,5]‐hydrogen‐transfer process is described. Treatment of γ‐benzyl‐protected Co~2~(CO)~6~‐α,γ‐acetylenic diols with BF~3~⋅OEt~2~ provides bis‐homopropargylic alcohols. The reaction occurs within seconds, tolerates a wide range of funct