Toward the second-generation synthesis o
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Osamu Kataoka; Shinji Kitagaki; Nobuhide Watanabe; Jun-ichi Kobayashi; Sei-ichi
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Article
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1998
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Elsevier Science
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French
β 380 KB
A highly eJicient construction of the 2,8-dioxabicyclo[l2,1]octane core structure of zaragozic acids, inhibitors of the enzyme squalene synthase, hns been achieved by exploiting the sequence of rhodium(II)-mediated intramolecular carbonyl ylide formation from an a-diazo ester and stereocontrolled I.