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1,3-Dipolar cycloaddition of C-(2-thiazolyl)nitrones to chiral acrylates. Synthesis of enantiopure α-amino-2-alkylthiazoles and 5-formylpyrrolidin-2-ones

✍ Scribed by Tomas Tejero; Alessandro Dondoni; Isabel Rojo; Francisco L Merchán; Pedro Merino


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
1023 KB
Volume
53
Category
Article
ISSN
0040-4020

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✍ Usama A.R. Al-Timari; L̆ubor Fis̆era; Igor Goljer; Peter Ertl 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 540 KB

The synthesis of 2-phenyl-3-aryl and 2-phenyl-3-aroyl derivatives 5-(1,2-O-isopropylidene-alpha-D-xylo-tetrofuranos-4-yl)isoxazolidi ne (3) from nitrones and 5,6-dideoxy-1,2-O-isopropylidene-alpha-D-xylo-hex-5- enofuranose (1) is described. The 1,3-dipolar cycloaddition reactions given mainly anti a