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1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: Structure–affinity/activity relationship at α1-adrenoceptor subtypes and at 5-HT1A receptors

✍ Scribed by Silvia Franchini; Adolfo Prandi; Annamaria Baraldi; Claudia Sorbi; Annalisa Tait; Michela Buccioni; Gabriella Marucci; Antonio Cilia; Lorenza Pirona; Paola Fossa; Elena Cichero; Livio Brasili

Book ID
108116448
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
747 KB
Volume
45
Category
Article
ISSN
0223-5234

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✍ Claudia Sorbi; Silvia Franchini; Annalisa Tait; Adolfo Prandi; Rossella Gallesi; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB 👁 1 views

## Abstract Conformational restriction of naftopidil led to the discovery of a new class of ligands with a 1,3‐dioxolane (1,3‐oxathiolane, 1,3‐dithiolane) structure that bind to α~1~ adrenoceptor subtypes and 5‐HT~1A~ receptors. Adequate structural modifications address the selectivity toward one o