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1,3-Dimethyl-3-acyltriazenes: synthesis and chemistry of a novel class of biological methylating agents

✍ Scribed by Smith, Richard H.; Mehl, Andrew F.; Hicks, Anne; Denlinger, Cheryl L.; Kratz, Lisa; Andrews, A. Wesley; Michejda, Christopher J.

Book ID: 127289419
Publisher: American Chemical Society
Year: 1986
Tongue: English
Weight: 989 KB
Volume: 51
Category: Article
ISSN: 0022-3263
DOI: 10.1021/jo00370a002

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## Abstract __The cytotoxic activities of 23 new__ iso__combretastatin A derivatives with modifications on the B‐ring were investigated. Several compounds exhibited excellent antiproliferative activity at nanomolar concentrations against a panel of human cancer cell lines. Compounds__ iso__FCA‐4 (*