1,3-Cycloaddition of nitrile oxides in ionic liquids. An easier route to 3-carboxy isoxazolines, potential constrained glutamic acid analogues

✍ Scribed by Dario Conti; Manuela Rodriquez; Alessandro Sega; Maurizio Taddei

• Book ID: 104253869
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 154 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)01195-x

✦ Synopsis

Several improvements in the cycloaddition of carboethoxyformonitrile oxide (CEFNO) with different alkenes are observed in the ionic liquids [bmim][BF 4 ] and [bmim][PF 6 ]. The possibility of obtaining good yields of the corresponding isoxazolines opens the way towards parallel collections of glutamic acid (Glu) analogues.