13-cis-retinoic acid in conglobate acne. A follow-up study of 14 trial centers
✍ Scribed by R. Hennes; A. Mack; H. Schell; H. J. Vogt
- Book ID
- 104764683
- Publisher
- Springer-Verlag
- Year
- 1984
- Tongue
- English
- Weight
- 543 KB
- Volume
- 276
- Category
- Article
- ISSN
- 0340-3696
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✦ Synopsis
A follow-up was done on the patients of the German multicenter study with severe conglobate acne who had been treated with different dosages of 13-cisretinoic acid. Eighty-seven patients were monitored from 12 to 21 months. Optimal long-term therapeutic effects were obtained with an initial dose of 1.0 mg/kg body weight, for 3 months, followed by another 3-month-treatment period with 0.2 mg/kg body weight. Six months after the termination of therapy 96 % of the patients were still in remission and 81% after 12 months. Comparative figures for the administration of doses were 84 % as opposed to 47 % (0.5 -~ 0.2 mg/kg body wt.) and 74 % as opposed to 37 % (0.2 ~ 0.2 mg/kg body wt.), respectively. It is suggested from the present data that a high initial dosage of 13-cis-retinoic acid be chosen in order to obtain optimal long-term therapeutic effects. Transiently elevated lipid levels as well as other tolerable side effects return to normal within 3 months at the latest after discontinuation of treatment.