129. Zaburzenia liczby kopii genów erbB-1 i erbB-2 i ich związek z danymi klinicznymi u leczonych operacyjnie chorych na niedrobnokomórkowego raka płuca
✍ Scribed by K. Konopa; A. Żaczek; K. Bielawski; J. Jakóbkiewicz; M. Żylicz; J. Jassem
- Publisher
- Wielkopolskie Centrum Onkologii
- Year
- 2003
- Tongue
- Polish
- Weight
- 194 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1507-1367
No coin nor oath required. For personal study only.
✦ Synopsis
Methods: A group of 110 patients surgically treated because of SCC was analyzed. Paraffin-embedded pathologic material underwent cytometric analysis. Post-operative follow-up was performed with standard follow-up visits. The 2 tests toxstatistical analysis was carried out using Mann-Whitney's and compare the following parameters in both groups: clinical staging, grading, tumor size, distant and local metastasis, tumor location, type of surgical procedure, local recurrence and survival time. The survival curves were drawn using the Kaplan-Meier method and two and five years survival rate were assessed. Clinical staging, regional metastasis and ploidy, having a great impact on survival rates, were analyzed with multivariational analysis.
Results: 50 (45%) tumors were DNA aneuploid. There were no significance between the ploidy groups in clinical staging, grading, tumor size and location and type of surgical procedure. The two years survival rate in patients with aneuploid cancers (16,7%) was significantly worse than in those with diploid tumors (50%)(p<O,05). This significance wasn't observed five years after surgery between aneuploid (13,5%) and diploid cancers (20,5%).
Conclusions: DNA content abnormalities were found to be an important prognostic factor in patients with SCLC in two years follow up. However the DNA ploidy might not be a predictive factor on long term (5 years) survival rate in this group of patients.