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128 Investigation of RAS and PI 3-kinase signaling networks in cancer using synthetic lethal screens

✍ Scribed by J. Downward


Book ID
119599877
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
45 KB
Volume
7
Category
Article
ISSN
1359-6349

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## Abstract The RAS‐MAPK, PI (3)K signaling pathways form a network that play a central role in tumorigenesis. The __BRAF__, __KRAS__ and __PI3KCA__ genes code 3 partners of this network and have been found to be activated by mutation in colorectal cancer; these mutations lead to unrestricted cell