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127* Oxidative stress activates ERK1/2 but no NF-κB signalling in CFTR-deficient bronchial epithelial cells

✍ Scribed by E. Boncoeur; E. Bonvin; C. Muselet-Charlier; A. Henrion-Caude; D.C. Guenert; A. Clement; J. Jacquot; O. Tabary

Book ID: 118641181
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 60 KB
Volume: 6
Category: Article
ISSN: 1569-1993
DOI: 10.1016/s1569-1993(07)60116-7

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## Abstract We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine IL‐8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways. In this study we investigated the mechanisms in