The finger motif is a tandemly repeated DNA-binding domain recently identified in the primary structure of several eukaryotic transcriptional regulatory proteins. It has been proposed that some members of the finger-gene family are implicated in both normal cell proliferation and differentiation. We
โฆ LIBER โฆ
127 Localization of the human P10 finger gene on a chromosomal region (3p21) deleted in human lung cancers
โ Scribed by E. Donti; L. Lanfrancone; A. Pascucci; K. Huebnert; G. Venti; F. Grignani; C.M. Croce; L. Lania; P.G. Pelicci
- Book ID
- 119104517
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 111 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0165-4608
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We examined 149 lung cancer cell lines for homozygous deletions using 24 DNA markers, which were mapped and ordered in chromosome band 9p21, to define the target regions for 9p21 deletions in human lung cancer. Homozygous deletions were detected in 39 (26%) cell lines and clustered at 2 independent
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