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1261 REDUCTION OF TIP47 IMPROVES HEPATIC STEATOSIS AND GLUCOSE HOMEOSTASIS IN DIET-INDUCED OBESE MICE

โœ Scribed by Carr, R.M.; Patel, R.; Rao, V.; Graham, M.; Crooke, R.; Ahima, R.S.


Book ID
122040220
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
40 KB
Volume
54
Category
Article
ISSN
0168-8278

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In this study, we investigated the role of acyl-coenzyme A:diacylglycerol acyltransferase 2 (DGAT2) in glucose and lipid metabolism in obese mice by reducing its expression in liver and fat with an optimized antisense oligonucleotide (ASO). High-fat diet-induced obese (DIO) C57BL/6J mice and ob/ob m