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126. Comparative Analysis of brain lipids in Mice, Cats, and Humans with Sandhoff disease

✍ Scribed by Thomas Seyfried; Rena Baek; Douglas Martin; Nancy Cox; Christine Denny; Melanie McNally; Daniel Kirschner

Book ID
116988560
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
41 KB
Volume
96
Category
Article
ISSN
1096-7192

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## Abstract Caloric restriction (CR), which improves health and increases longevity, was studied as a therapy in a hexosaminidase Ξ² knockout mouse model of Sandhoff disease (SD), an incurable neurodegenerative disease involving accumulation of brain ganglioside GM2 and asialo‐GM2 (GA2). Adult mice