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[125]RTI-55, a high affinity cocaine analog, labels two binding sites in human caudate membranes possibly related to the 5-HT transporter

โœ Scribed by M.L. Silverthom; C.M. Dersch; J.S. Partilla; F.I. Carroll; D.L. Matecka; K.C. Rice; R.B. Rothman

Book ID
118856911
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
168 KB
Volume
35
Category
Article
ISSN
0006-3223

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Studies of the biogenic amine transporters. VII. Characterization of a novel cocaine binding site identified with [125I]RTI-55 in membranes prepared from human, monkey and guinea pig caudate
โœ Richard B. Rothman; Mayme L. Silverthorn; John R. Glowa; Dorota Matecka; Kenner ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 299 KB ๐Ÿ‘ 2 views

125 I]RTI-55 is a cocaine analog with high affinity for dopamine (DA) and serotonin (5-HT) transporters. Quantitative ligand binding studies revealed a novel high affinity [ 125 I]RTI-55 binding site assayed under 5-HT transporter (SERT) conditions which has low affinity for almost all classic biog