1,25(OH)2-Vitamin D-3 stimulates phospholipase A2 activity via a guanine nucleotide-binding protein in chick myoblasts
✍ Scribed by Ana R. De Boland; Susana Morelli; Ricardo Boland
- Book ID
- 115741533
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 592 KB
- Volume
- 1257
- Category
- Article
- ISSN
- 0005-2760
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## Abstract Phospholipase A~2~ (PLA~2~) is pivotal in the rapid membrane‐mediated actions of 1,25‐dihydroxyvitamin D3 [1α,25(OH)~2~D~3~]. Microarray analysis indicated that PLA~2~ activating protein (PLAA) mRNA is upregulated 6‐fold before rat growth plate cells exhibit 1α,25(OH)~2~D~3~‐dependent p
The steroid hormone 1␣,25(OH) 2 -vitamin D 3 (1␣,25(OH) 2 D 3 ) generates biological responses in intestinal and other cells via both genomic and rapid, nongenomic signal transduction pathways. We examined the hypothesis that 1␣,25(OH) 2 D 3 action in chick enterocytes may be linked to pathways invo