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[125I-Tyr1]biphalin binding to opioid receptors of rat brain and NG108-15 cell membranes

โœ Scribed by Jirina Slaninova; Suzanne M. Appleyard; Aleksandra Misicka; Andrzej W. Lipkowski; Richard J. Knapp; Steven J. Weber; Thomas P. Davis; Henry I. Yamamura; Victor J. Hruby


Book ID
117175573
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
479 KB
Volume
62
Category
Article
ISSN
0024-3205

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The N-terminal tripeptide enkephalin analogue, Tyr-D-Ala-Gly, was dimerized at the C-terminus systematically with a series of a,w-diaminoalkanes, NH2-(CH,),-NH, (n = 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, and 22). The binding affinities of dimers for 6 opiate receptors in rat brain were evaluated and c