## Abstract We are interested in determining the signaling pathways for 1,25‐dihydroxyvitamin D~3~ (1,25D)‐induced differentiation of HL60 leukemic cells. One possible candidate is Raf‐1, which is known to signal cell proliferation and neoplastic transformation through MEK, ERK, and downstream targ
✦ LIBER ✦
1,25-Dihydroxyvitamin D3increases human cystatin A expression by inhibiting the Raf-1/MEK1/ERK signaling pathway of keratinocytes
✍ Scribed by Hidetoshi Takahashi; Masaki Ibe; Masaru Honma; Akemi Ishida-Yamamoto; Yoshio Hashimoto; Hajime Iizuka
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 297 KB
- Volume
- 295
- Category
- Article
- ISSN
- 0340-3696
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## Abstract 1α,25‐dihydroxyvitamin D~3~ (1α,25(OH)~2~D~3~) stimulates the activity of steroid sulphatase (STS) in myeloid cells [Hughes et al., 2001, 2005]. This was attenuated by inhibitors of phospholipase D (PLD) (__n__‐butanol, 2,3‐diphosphoglyceric acid, C~2~‐ceramide) and phosphatidate phosph