1,25-Dihydroxyvitamin D3 Treatment Shrinks Uterine Leiomyoma Tumors in the Eker Rat Model
β Scribed by Halder, S. K.; Sharan, C.; Al-Hendy, A.
- Book ID
- 115534837
- Publisher
- Society for the Study of Reproduction
- Year
- 2012
- Tongue
- English
- Weight
- 463 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0006-3363
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## Abstract Eker rats carry a defect in the __Tscβ2__ tumor suppressor gene and female Eker rats develop uterine leiomyoma with a high frequency. The presentation, response to hormones and molecular alterations in these mesenchymal smooth muscle tumors, closely resembles their cognate human disease
Five analogs of 1 alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3] [1], 26,27-dimethyl-1 alpha,25-dihydroxyvitamin D3 [1,25(OH)2(Me)2D3] [2], 26,27-dimethyl-1 alpha,25-dihydroxyvitamin D3 [1,25(OH)2(Et)2D3] [3], 26,27-dipropyl-1 alpha,25-dihydroxyvitamin D3 [1,25(OH)2(Pr)2D3] [4], 26,27-dimethyl-24,24-dif