1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3), a metabolically active form of vitamin D, is shown to increase in a dose-dependent manner the cellular pool of NGF mRNA in murine L-929 fibroblasts cultured in a serum-free medium. This effect can be detected as early as 3 hours after 1,25-(OH)2D3 addition an
✦ LIBER ✦
1,25-Dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells
✍ Scribed by Isabelle Neveu; Philippe Naveilhan; Fre´de´ric Jehan; Christel Baudet; Didier Wion; Hector F. De Luca; Philippe Brachet
- Book ID
- 119138869
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 985 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0169-328X
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The vitamin D receptor (VDR) is a nuclear receptor that mediates the effect of the active metabolite of vitamin D3, the 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3). To investigate the potential role of this hormone in the peripheral nervous system, we have studied the VDR expression in Schwann cells. Th